재조합 제2형 인간골형성단백질이 코팅된 삼인산칼슘을 이용한 발치창 보존술: 3개월 간의 무작위 전향적 임상연구
Extraction socket preservation using β-tricalcium phosphate coated with recombinant human bone morphogenetic protein-2: Randomized clinical prospective study
이효정, 김명진, 김영균, 윤필영,
소속 상세정보
이효정 ( Lee Hyo-Jung ) - 분당서울대학교병원 치과치주과
김명진 ( Kim Myoung-Jin ) - 인제대학교 부산백병원 치과 치주과
김영균 ( Kim Young-Kyun ) - 분당서울대학교병원 치과 구강악안면외과
윤필영 ( Yun Pil-Young ) - 분당서울대학교병원 치과 구강악안면외과
KMID : 0353320110350020110
Abstract
Purpose: In our study, we evaluated the stability and clinical effect of bone graft material coated with recombinant human bone morphogenetic protein-2 (rhBMP-2). Materials and Methods: 25 patients (male: 12, female: 13) were selected who had the premolar or molar which should be extracted due to vertical alveolar bone destruction, but remaining alveolar bone height was greater than 50%. After tooth extraction, the control group was grafted with β-tricalcium phosphate and experimental group was grafted with β-TCP with rhBMP-2. The healing condition of each group was evaluated and compared with CT imaging. After 3 month of operation, we evaluated amount of bone resorption with vertical height and width. Results: In control group, the change in alveolar bone height was -1.087±1.413 mm and the experimental group was -0.059±0.960 mm. In the change of alveolar bone width, control group was 0.006±1.149 mm in 25% ESL (Extraction Socket Level). And in 50% ESL, control group was 0.542±1.157 mm and experimental group was 1.239±1.249 mm. And in 75% ESL, control group was 1.405±1.753 mm and experimental group was 1.864±2.310 mm. In comparison of bone width between pre and post operation in each group, there was statistical significant difference only in control group, which means the experimental group has effect of bone preservation. Conclusion: In our analysis, β-TCP coated with rhBMP-2 is appeared more effective in socket preservation than β-TCP (P<0.05).
키워드
Tricalcium phoshphate; rhBMP-2
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